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Date: Style a. Using household measuring spoons and cups Q: Why are families interested in pursuing the ketogenic diet for epilepsy?
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Researchers have come up with many theories for why the keto diet helps to reduce seizures, but the exact mechanism remains unclear. Most patients who stick to the diet show dramatic cognitive improvement and halve their number of seizures. Medications can be reduced or discontinued. Some kids even are cured completely by the diet. But there can be no cheating: A little off-diet lick of sugar or a nibble of bread could immediately trigger a seizure.
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Fat content makes up around 90% of the diet with the rest coming from carbs and proteins combined May be too liberal in carbohydrate level to invoke good seizure control
Pathophysiology the Middle East Subscribe with Amazon Patti Wolff says: He grimaces as he slurps the last few drops of pure oil through a straw, but he eats it all without complaint. This strange diet has given him his life back.
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Can the Ketogenic Diet Enhance Endurance Performance? What is the Glycemic Index?
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Other Hearst Subscriptions Patient-Identified Quality Measures To identify which genes might be involved, the researchers used microarray “gene chips” to examine changes in gene expression for more than 7,000 rat genes simultaneously. They focused on the hippocampus, a region of the brain known to play an important role in many kinds of epilepsies. More than 500 of the genes they examined were correlated with treatment with the KD. The most striking finding was the coordinated up-regulation of genes involved in energy metabolism.
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Infantile spasms respond well to the ketogenic diet [15, Class II]. Epilepsy.com’s Keto News includes summaries of cutting edge research and helpful hints for people with epilepsy, parents, and caregivers who receive or provide diets for the treatment of epilepsy.
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Folate Deficiency A systematic review in 2016 found and analysed seven randomized controlled trials of ketogenic diet in children and young people with epilepsy. The trials were done among children and young people for whom drugs failed to control their seizures, and only one of the trials compared a group assigned to ketogenic diet with a group not assigned to one. The other trials compared types of diets or ways of introducing them to make them more tolerable. Nearly 40% of the children and young people had half or fewer seizures with the diet compared with the group not assigned to the diet. Only about 10% were still on the diet after a few years. Adverse effects such as hunger and loss of energy in that trial were common, with about 30% experiencing constipation.
In Celebration 36. Schwartz RH, Eaton J, Bower BD, Aynsley-Green A. Ketogenic diets in the treatment of epilepsy: short-term clinical effects. Dev Med Child Neurol. 1989;31(2):145-151.
The authors conclude that for treatment of refractory epilepsy, current data do not provide an evidential basis for the ketogenic diet and modified Atkins diet use. Until more data are available, they should only be used as a last resort.
Epilepsy Foundation (Greater Chicago): “Ketogenic Diet.” Ketogenic diets in the treatment of epilepsy Playing Sports and Other Activities
Neurostimulation for Epilepsy 27. Kossoff EH, Cervenka MC, Henry BJ, Haney CA, Turner Z. A decade of the modified Atkins diet (2003-2013): results, insights, and future directions. Epilepsy Behav. 2013;29(3):437-442.
8. Bough KJ, Rho JM. Anticonvulsant mechanisms of the ketogenic diet. Epilepsia. 2007;48:43–58. [PubMed] Other factors that can affect the glycemic response include the fibre content, cooking methods and processing of foods. Likewise, adding in protein and fat to carbohydrate sources can also effect its glycemic response.
Before starting a patient on the diet, we identify and overcome any barriers the family may have. Then we teach them how to identify and count carbs, how to make food and how the metabolic system works. We give families tools to address the different scenarios they will encounter – whether that’s following the diet at school or avoiding hidden carbs in items like lotion, shampoo and toothpaste.
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However, the main difference between children and adults is persistence of the effect of KD after discontinuing the diet. In a small proportion of children who become seizure free on the diet, the seizures do not recur even after the diet is stopped. In adults, this has not been seen so far.
Visiting The Doctor Stress and Epilepsy Martin K, Jackson CF, Levy RG, Cooper PN. Ketogenic diet and other dietary treatments for epilepsy. Cochrane Database of Systematic Reviews. September 2016. doi:10.1002/14651858.cd001903.pub3.
Yellen’s lab had previously linked ketone bodies like those from the high-fat epilepsy diet to the activation of a type of potassium channel in neurons. Yellen hypothesized that the diet worked because ketone bodies from fat provide enough neurons to fuel normal function, but when a seizure threatens, the associated potassium channel can shut the storm down. Dietary effects, however, are broad and complex, so it was impossible to say for sure.
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